Lack of inherited mutations of PTPRD in familial melanoma and melanoma-astrocytoma syndrome.
نویسندگان
چکیده
Department of Oncology, Lombardi Cancer Center, Georgetown University School of Medicine, Washington, DC, USA Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA Correspondence T. Waldman, e-mail: [email protected]
منابع مشابه
Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma.
An additional tumor suppressor gene on chromosome 9p telomeric to the CDKN2A/B locus has long been postulated to exist. Using Affymetrix 250K single nucleotide polymorphism arrays to screen for copy number changes in glioblastoma multiforme (GBM), we detected a high frequency of deletions of the PTPRD gene, which encodes a receptor protein tyrosine phosphatase at chromosome 9p23-24.1. Missense ...
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Cancer is a genetic condition. Some cancers are inherited, but most are caused by mutations in somatic cells. The cause of these mutations is inherent error in the transcription of DNA or exposure to carcinogens. Malignant melanoma is the most serious type of skin cancer which develops from pigment-containing cells known as melanocytes. The most potent risk factors for melanoma is the presence ...
متن کاملMutational and Functional Analysis of the TumorSuppressor <fc>PTPRD</fc> in Human Melanoma
Protein tyrosine phosphatases (PTPs) tightly regulate tyrosine phosphorylation essential for cell growth, adhesion, migration, and survival. We performed a mutational analysis of the PTP gene family in cutaneous metastatic melanoma and identified 23 phosphatase genes harboring somatic mutations. Among these, receptor-type tyrosine–protein phosphatase delta (PTPRD) was one of the most highly mut...
متن کاملMelanoma-Astrocytoma syndrome
Characterised by families with cutaneous malignant melanoma (CMM) and nervous system tumours. Initially described in a family with malignant melanoma and/or cerebral astrocytoma in eight members over three generations. Astroctytomas and cutaneous malignant melanoma have been identified in a number of well defined syndromes such as neurofibromatosis, Turcot’s, Lynch type II cancer, LiFraumeni an...
متن کاملMutational and functional analysis of the tumor-suppressor PTPRD in human melanoma.
Protein tyrosine phosphatases (PTPs) tightly regulate tyrosine phosphorylation essential for cell growth, adhesion, migration, and survival. We performed a mutational analysis of the PTP gene family in cutaneous metastatic melanoma and identified 23 phosphatase genes harboring somatic mutations. Among these, receptor-type tyrosine-protein phosphatase delta (PTPRD) was one of the most highly mut...
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ورودعنوان ژورنال:
- Pigment cell & melanoma research
دوره 22 4 شماره
صفحات -
تاریخ انتشار 2009